How Platelet-Rich Plasma (PRP) Works, Results, Usage, and Side Effects

Androgenetic alopecia (AGA), commonly known as hair loss, affects a significant portion of the global population, causing psychosocial distress and impacting self-esteem. Platelet-rich plasma (PRP) therapy, a relatively new approach in dermatological treatments, has been gaining traction for its potential in managing hair loss. This article delves into the biological mechanism of PRP and examines studies that explore its efficacy in treating AGA.

Close up injecting platelet rich plasma (PRP) as an FDA approved treatments for hair loss

What is Platelet-Rich Plasma (PRP)?

Platelet-Rich Plasma (PRP) therapy is an advanced treatment used to combat hair loss. This method involves drawing a patient’s blood, processing it to concentrate the platelets – cell fragments vital for healing and growth – and then re-injecting this platelet-rich plasma back into the patient’s scalp. PRP is rich in growth factors, which are essential for stimulating inactive or newly implanted hair follicles into an active growth phase. This process can lead to hair regrowth and a thicker, fuller head of hair. PRP therapy is favored for its natural approach, as it uses the body’s own healing mechanisms. It is especially popular among patients seeking a minimally invasive, yet effective solution for hair loss. The treatment is generally well-tolerated, with minimal discomfort and downtime, making it an attractive option for those looking to address hair thinning or loss.

History of Platelet-Rich Plasma (PRP)

The history of Platelet-Rich Plasma (PRP) therapy for hair loss represents a relatively recent development in the realm of hair restoration. Despite PRP’s medical applications dating back to the 1970s for various purposes, its application for stimulating hair regrowth gained substantial traction in the early 21st century.

To trace its origins, PRP therapy’s roots lie in its medical applications. Initially, it found use in orthopedic and dental surgery to facilitate tissue healing and promote bone regeneration. Remarkably, it was the recognition of PRP’s regenerative capabilities that sparked the idea of harnessing it for hair growth.

The first documented use of PRP for addressing hair loss emerged in a small study published in 2006. In this study, researchers explored its potential in stimulating hair follicles, effectively marking the inception of PRP therapy for hair loss treatment. Over the subsequent decade, PRP therapy gained attention among dermatologists and hair restoration specialists due to its minimally invasive nature and relatively low risk of side effects.

As interest in PRP therapy continued to grow, numerous studies and clinical trials were conducted to assess its effectiveness in treating various forms of hair loss, including androgenetic alopecia (male and female pattern baldness) and alopecia areata. This ongoing research not only solidified PRP’s role but also paved the way for its widespread clinical adoption in the field of hair restoration. Today, PRP therapy is frequently offered as a treatment option, either as a standalone therapy or in conjunction with other hair loss treatments. Ongoing research efforts remain dedicated to refining PRP protocols and deepening our understanding of its intricacies, further cementing its place in the evolving landscape of hair restoration.

How Platelet-Rich Plasma (PRP) Treats Hair Loss

The science behind Platelet-Rich Plasma (PRP) therapy for hair loss involves several key biological mechanisms that are believed to contribute to its effectiveness:

  • Growth Factors: Platelets in the blood contain various growth factors, such as platelet-derived growth factor (PDGF), transforming growth factor-beta (TGF-β), and vascular endothelial growth factor (VEGF). These growth factors play a crucial role in tissue repair, regeneration, and angiogenesis (the formation of new blood vessels).
  • Activation of Stem Cells: PRP is thought to activate and stimulate stem cells located in and around hair follicles. These stem cells have the potential to transform into hair follicle cells and contribute to hair regrowth.
  • Follicle Rejuvenation: PRP therapy is believed to promote the rejuvenation of dormant or miniaturized hair follicles. By stimulating these follicles, PRP encourages them to transition into the active growth phase (anagen phase) and produce thicker, healthier hair strands.
  • Angiogenesis: PRP contains growth factors that can stimulate the formation of new blood vessels in the scalp (angiogenesis). Improved blood flow to the hair follicles can enhance the delivery of nutrients and oxygen, promoting hair follicle health and function.
  • Anti-Inflammatory Effects: Inflammatory processes are associated with some types of hair loss. PRP’s anti-inflammatory properties may help reduce inflammation in the scalp, creating a more conducive environment for hair growth.
  • Cell Proliferation: PRP can encourage the proliferation (multiplication) of cells involved in hair growth, such as dermal papilla cells. This cell proliferation is thought to contribute to the regrowth of hair.
  • Collagen Production: PRP may stimulate the production of collagen, a structural protein that provides support to the skin and hair follicles. Increased collagen levels can help strengthen hair follicles and improve their longevity.

Empirical Evidence

The potential of PRP in hair restoration has been the subject of numerous clinical investigations:

  • Gentile et al. (2015) conducted a study on 23 patients, administering PRP injections. The results showed a significant increase in hair density and the caliber of the hair shaft, demonstrating the treatment’s efficacy.
  • Cervelli et al. (2014) explored the synergistic effects of PRP combined with hair transplant in 48 patients. Findings indicated a quicker post-transplant recovery and a higher survival rate of the transplanted follicles in the PRP-treated group.
  • Alves and Grimalt (2018) undertook a systematic review of multiple clinical trials on PRP for AGA. The majority of these studies manifested improvements in hair density, thickness, and overall patient satisfaction post-treatment.
Clinical trial results of using platelet-rich plasma (PRP)

Clinical trial results showing an increase in the number of follicles after using platelet-rich plasma (PRP) compared to the baseline. 


The results of Platelet-Rich Plasma (PRP) therapy for hair loss can vary from person to person, and individual responses may differ based on factors such as the underlying cause of hair loss, the extent of hair loss, and the specific PRP protocol used. However, here are some potential outcomes and results associated with PRP therapy for hair loss:

  • Improved Hair Density: Many individuals who undergo PRP therapy report an increase in hair density in the treated areas. This means that the hair appears thicker and more abundant, making the scalp less visible.
  • Hair Regrowth: PRP therapy may stimulate the regrowth of hair in areas where hair follicles are still active but producing thin or fine hair strands. Individuals may notice the growth of new, healthier hair.
  • Slowed Hair Loss: PRP therapy can help slow down the progression of hair loss. By strengthening existing hair follicles and promoting hair growth, PRP may reduce the rate at which hair is shed.
  • Thicker and Stronger Hair: PRP is believed to enhance the quality of existing hair, making it thicker, stronger, and more resilient. This can result in improved hair texture and less breakage.
  • Enhanced Hair Follicle Health: PRP therapy may contribute to the overall health of hair follicles. Healthier follicles are more likely to produce robust, long-lasting hair.
  • Minimal Downtime: PRP therapy is minimally invasive and typically involves little to no downtime. Patients can usually resume their regular activities shortly after treatment.
  • Long-Lasting Results: While individual results may vary, some individuals experience long-lasting benefits from PRP therapy. Maintenance sessions may be recommended to sustain results over time.
Before and after using platelet-rich plasma (PRP) to treat hair loss

Improved hair growth and density after continued use of platelet-rich plasma (PRP).

Platelet-Rich Plasma (PRP) Procedure

Platelet-Rich Plasma (PRP) therapy for hair loss is a medical procedure typically performed by a qualified healthcare provider or dermatologist. Here’s an overview of the steps involved in a typical PRP treatment session for hair loss:

  • Consultation: Before undergoing PRP therapy, individuals usually have a consultation with their healthcare provider. During this consultation, the provider evaluates the patient’s hair loss condition, medical history, and overall health to determine if PRP therapy is a suitable treatment option.
  • Blood Collection: On the day of the PRP procedure, a small amount of the patient’s blood is drawn, typically from the arm, using a standard blood collection technique similar to a regular blood test.
  • Centrifugation: The collected blood is then processed in a centrifuge machine. The centrifuge spins the blood at high speeds, separating it into its various components. This process isolates the platelet-rich plasma from the rest of the blood.
  • Preparation of PRP: The platelet-rich plasma is carefully separated and collected. It contains a concentrated amount of platelets, growth factors, and other bioactive substances.
  • Anesthesia: To minimize discomfort during the PRP injection, the scalp is often numbed with a local anesthetic. This helps ensure that the procedure is virtually painless.
  • Injection: The PRP solution is injected directly into the targeted areas of the scalp experiencing hair loss. The injections are strategically administered to reach the hair follicles that need stimulation.
  • Recovery: Following the procedure, there is usually no need for a lengthy recovery period. Patients can typically resume their normal activities the same day.
  • Follow-Up Sessions: PRP therapy for hair loss typically involves a series of sessions scheduled over a few months. The exact number and frequency of sessions may vary depending on the patient’s individual needs and the practitioner’s recommendations.

Safety and Side Effects

Platelet-Rich Plasma (PRP) therapy is generally considered safe with minimal risk of significant side effects. Since PRP uses the patient’s own blood components, the risk of allergic reactions or infections is very low. However, like any medical procedure, there can be some potential side effects and considerations to be aware of:

  • Mild Discomfort: Some individuals may experience mild discomfort or pain at the injection site immediately after the procedure. This discomfort is typically short-lived and can be managed with over-the-counter pain relievers if necessary.
  • Swelling and Bruising: Swelling and bruising at the injection site can occur, but these side effects are usually temporary and resolve within a few days.
  • Infection: Although the risk is low, there is a potential risk of infection at the injection site. Healthcare providers take precautions to maintain a sterile environment during the procedure to minimize this risk.
  • Bleeding: Some patients may experience minor bleeding at the injection sites, particularly if they have a bleeding disorder or are taking blood-thinning medications.
  • Scalp Tenderness: The scalp may feel tender or sensitive after the procedure, but this typically subsides within a few days.
  • Allergic Reactions: Allergic reactions to PRP therapy are extremely rare since the patient’s own blood is used. However, patients with a known allergy to any component of blood should inform their healthcare provider.


PRP, with its rich ensemble of growth factors and cytokines, presents a compelling case for its use in the realm of hair restoration. The fundamental mechanism revolves around stimulating dormant follicles, promoting angiogenesis, and ensuring cellular proliferation, providing a conducive environment for hair growth.

Clinical studies, albeit still in their nascent stages, consistently indicate a positive trend in terms of hair density, follicular survival, and patient satisfaction. With its natural origin and minimal side effects, PRP may soon carve its niche as a mainstay in the treatment spectrum for androgenetic alopecia.

However, as with all emerging treatments, further large-scale, randomized, and controlled studies are essential to firmly establish PRP’s efficacy and long-term effects.


  • Gentile, P., et al. (2015). The Effect of Platelet-Rich Plasma in Hair Regrowth: A Randomized Placebo-Controlled Trial. Stem Cells Translational Medicine, 4(11), 1317-1323.
  • Cervelli, V., et al. (2014). The effect of autologous activated platelet-rich plasma (AA-PRP) injection on pattern hair loss: Clinical and histomorphometric evaluation. BioMed Research International, 2014, 760709.
  • Alves, R., & Grimalt, R. (2018). A Review of Platelet-Rich Plasma: History, Biology, Mechanism of Action, and Classification. Skin Appendage Disorders, 4(1), 18-24.

Note: Always seek professional medical advice before starting any treatment.

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