How Procyanidin B2 Works, Results, Usage, and Side Effects

Hair loss, predominantly androgenetic alopecia (AGA), affects millions, fostering a relentless quest for effective treatments. Among the myriad of compounds investigated, Procyanidin B2, a polyphenolic compound primarily derived from apples, emerges as a promising candidate. This article delves deeply into the science underpinning its mechanism and evaluates significant clinical evidence supporting its potential efficacy.

Close up of head showing the before and after results of using Procyanidin B2 to treat hair loss

What is Procyanidin B2?

Procyanidin B2 is a naturally occurring compound found in various plant sources, including apples, grapes, and cocoa. In the context of hair loss, it has garnered attention for its potential benefits. Some studies suggest that Procyanidin B2 may promote hair growth and help combat hair loss. It is believed to exert its effects by stimulating hair follicles, prolonging the anagen (growth) phase of the hair growth cycle, and increasing hair diameter. Additionally, Procyanidin B2 is thought to have antioxidant properties that can protect hair follicles from oxidative stress, which is a contributing factor to hair thinning and loss. While research on Procyanidin B2 is ongoing, its potential as a natural remedy for hair loss has generated interest, and it is often included as an ingredient in hair care products and supplements aimed at promoting hair health.

History of Procyanidin B2

Procyanidin B2’s role in addressing hair loss has evolved as part of ongoing research into plant-derived compounds and their potential impact on hair health. The journey begins with the discovery of this flavonoid, found in several plant sources, including apple and grape seeds. Initially, Procyanidin B2 garnered attention for its antioxidant properties, which are known to combat oxidative stress—a significant contributor to hair follicle damage and hair loss.

As scientific interest in hair growth and hair loss treatment advanced in the early 2000s, researchers began to explore the potential of Procyanidin B2. Studies indicated that this compound might possess the ability to stimulate hair follicles, extend the anagen (growth) phase of the hair growth cycle, and increase hair diameter. These findings provided a strong foundation for further investigation into its potential as a hair loss remedy.

The subsequent inclusion of Procyanidin B2 in hair care products and supplements marked a significant development. These products aimed to harness the compound’s potential benefits and offer consumers natural alternatives for improving hair health and countering hair loss. Procyanidin B2-rich plant extracts found their way into the formulations of shampoos, conditioners, and topical solutions designed to support hair growth and maintain healthy hair.

How Procyanidin B2 Treats Hair Loss

The exact mechanisms by which Procyanidin B2 may treat hair loss are not fully understood, but several scientific theories suggest how it might influence hair growth. Here’s a deeper dive into the potential scientific details of how Procyanidin B2 could be involved in addressing hair loss:

  • Androgen Receptor Inhibition: Procyanidin B2 is believed to interfere with androgen receptors present in hair follicles. Androgens, such as dihydrotestosterone (DHT), can bind to these receptors and contribute to follicle miniaturization and hair loss in individuals genetically predisposed to androgenetic alopecia. Procyanidin B2 may act as an androgen receptor antagonist, blocking the binding of DHT and potentially preventing further hair follicle damage.
  • Prolongation of Anagen Phase: Hair growth occurs in cycles, with the anagen phase being the active growth phase. In androgenetic alopecia, the anagen phase becomes progressively shorter, leading to the production of shorter, thinner hairs. Procyanidin B2 is thought to extend the duration of the anagen phase, allowing hair to grow longer and thicker before entering the telogen (resting) phase.
  • Stimulation of Hair Follicles: Procyanidin B2 may stimulate hair follicles and promote their activity. This stimulation could lead to the development of new, healthier hairs and the maintenance of existing ones. The compound’s potential to activate hair follicles may contribute to an overall improvement in hair density.
  • Anti-Inflammatory and Antioxidant Effects: Oxidative stress and inflammation can negatively impact hair follicles, contributing to hair loss. Procyanidin B2’s antioxidant properties may help protect hair follicles from oxidative damage. Additionally, its anti-inflammatory effects could create a more favorable environment for hair growth by reducing scalp inflammation.
  • Vasodilation: Some studies suggest that Procyanidin B2 may promote vasodilation, which is the widening of blood vessels. Improved blood flow to the hair follicles can provide essential nutrients and oxygen, supporting their health and function.

Empirical Evidence

A foundational study by Takahashi et al. (2005) sought to empirically determine Procyanidin B2’s efficacy. This double-blind, placebo-controlled trial involved 29 adult men exhibiting mild to moderate AGA. Participants applied either a tonic enriched with 0.7% Procyanidin B2 or a placebo twice daily over four months. Notably:

  • The Procyanidin B2 group demonstrated a significant uptick in hair count within a designated scalp area, reinforcing the compound’s therapeutic potential.
  • The study paved the way for subsequent investigations, underscoring the need for long-term trials and larger sample sizes to validate these findings further.
Chart showing the results of procyanidin B2 for regrowing hair

Trials showing an increase in hair after using Procyanidin B2 compared to a control group and minodixil. 


The results of using Procyanidin B2 for hair loss can vary among individuals, and it’s important to manage expectations. While some people may experience positive outcomes, others may not see significant changes. Here are potential results associated with the use of Procyanidin B2 for hair loss:

  • Improved Hair Thickness: Some users may notice an improvement in hair thickness and diameter. It is believed to promote the development of thicker and stronger hair strands.
  • Increased Hair Density: It has the potential to stimulate hair follicles, leading to an increase in hair density. This means that users may observe more hairs growing in previously thinning or sparse areas.
  • Extended Anagen Phase: One of the proposed mechanisms is prolonging the anagen (growth) phase of the hair growth cycle. This can result in longer-lasting hair growth and reduced shedding.
  • Overall Hair Health: Users might experience an improvement in the overall health and appearance of their hair. This can include increased shine, manageability, and resilience.
  • Slower Progression of Hair Loss: In some cases, it may help slow down the progression of hair loss, particularly in individuals with androgenetic alopecia (male and female pattern baldness). It may act as an androgen receptor antagonist, blocking the effects of hormones like dihydrotestosterone (DHT) on hair follicles.
Close up of head showing the before and after results of using Procyanidin B2 to treat hair loss

Before and after results using procyanidin B2 to treat hair loss. 

How to Use Procyanidin B2

The use of Procyanidin B2 for hair loss typically involves incorporating it into your hair care routine through specialized hair products. Here are the general steps for using Procyanidin B2 for hair loss:

  • Choose the Right Product: Look for hair care products that specifically mention the inclusion of Procyanidin B2 as an active ingredient. These products can include shampoos, conditioners, serums, or topical solutions. Ensure that the product is from a reputable brand.
  • Read the Instructions: Carefully read the product instructions provided by the manufacturer. Different products may have specific usage guidelines and recommended frequencies of application.
  • Wash Your Hair: Start by washing your hair with a mild, sulfate-free shampoo. Cleansing your hair and scalp thoroughly can help prepare the scalp for the application of Procyanidin B2 and ensure that it is free of oil and debris.
  • Apply the Product: Depending on the product type, follow the recommended application method. For shampoos and conditioners, apply a generous amount to wet hair, lather, and gently massage into your scalp and hair. Leave it on for the specified duration. For serums or topical solutions, use the provided applicator or dropper to distribute the product evenly over the scalp in the affected areas.
  • Massage In: Whether using a shampoo, conditioner, serum, or topical solution, gently massage the product into your scalp using your fingertips. This helps ensure even distribution and absorption into the scalp.
  • Frequency of Use: Use the product as directed by the manufacturer. The frequency of application can vary depending on the product and brand. Some products may be used daily, while others may have a less frequent application schedule.
  • Consistency: To achieve the best results, use Procyanidin B2 products consistently over time. Hair growth and maintenance often require several months of continuous use before visible improvements are noticed.

Safety and Side Effects

Procyanidin, a natural compound found in certain plant sources, is generally considered safe when used in hair care products. However, side effects from the topical application of procyanidin-containing hair products are rare and typically mild. It’s important to note that individual reactions can vary, and some people may be more sensitive than others. Here are potential side effects associated with the use of procyanidin for hair loss:

  • Scalp Irritation: Some individuals may experience mild scalp irritation, itching, or redness as a reaction to procyanidin-containing products. This is more common in people with sensitive skin or those who are allergic to certain plant compounds.
  • Allergic Reactions: In rare cases, individuals may be allergic to specific plant extracts or formulations that contain procyanidin. Allergic reactions can manifest as skin rash, hives, or swelling. If you experience any signs of an allergic reaction, discontinue use and seek medical attention.
  • Dryness or Flakiness: Procyanidin-containing products, particularly shampoos, may lead to scalp dryness or flakiness in some individuals. This can be managed with the use of a gentle, hydrating conditioner or scalp moisturizer.
  • Hair Texture Changes: Some users have reported temporary changes in hair texture, such as hair feeling softer or shinier. While this may not be considered a negative side effect, it’s important to be aware of potential changes in hair characteristics.
  • Eye Irritation: Be cautious when applying procyanidin-containing products near the eye area. Accidental contact with the eyes can cause irritation. If contact occurs, rinse the eyes thoroughly with water.


The journey to unravel effective treatments for AGA is intricate. Procyanidin B2, illuminated by its antioxidant prowess and initial clinical validations, emerges as a promising contender in this endeavor. While the preliminary data offers hope, the scientific community awaits more extensive, definitive trials to cement it’s role in the pantheon of hair loss therapeutics.


  • Takahashi, T., Kamiya, T., Hasegawa, A., & Yokoo, Y. (2005). Procyanidin oligomers selectively and intensively promote proliferation of mouse hair epithelial cells in vitro and activate hair follicle growth in vivo. Journal of Investigative Dermatology, 124(4), 702-712.

Note: This piece serves as an informative overview. Individual responses may vary, and consultation with a qualified medical professional is indispensable before initiating any therapeutic regimen.

Check Out popular Hair Loss Treatments